Relationship between orthostatic hypotension and summary cerebral small vessel disease score

doi:10.3969/j.issn.1006-7795.2024.03.020

Abstract

Abstract: Objective To investigate the relationship between the presence and type of orthostatic hypotension (OH) and total cerebral small vessel disease (CSVD) score. Methods Consecutive 460 patients were recruited in this study from March, 2021 to September, 2023 and divided into No OH group, Early OH (EOH) group and delayed/prolonged OH (DPOH) group according to the presence and type of OH. A total CSVD score was evaluated using a 5-point scoring method (range 0－4). The correlation was analyzed between different OH groups and lacunes, white matter hyperintensities (WMH) scores, cerebral microbleeds (CMBs), basal ganglia-perivascular spaces (BG-PVS) as well as total CSVD score. Results The prevalence of EOH and DPOH was 10.00% and 17.17%, respectively, in these patients. There are significant differences in the proportion of lacunes and the distribution of degree of BG-PVS as well as total CSVD score among different OH groups (P<0.01). After adjusting for age, gender, hypertension and supine diastolic blood pressure, DPOH was an independent risk factor for lacunes (OR=2.421, 95% CI: 1.372－4.271, P=0.002), severe BG-PVS (OR=1.714, 95% CI:1.074－2.740, P=0.024), and higher total CSVD score (OR=1.791, 95% CI: 1.140－2.818, P=0.012).Conclusion Among CSVD patients, DPOH is more common than EOH and is an independent risk factor for higher total CSVD score.

Key words: orthostatic hypotension (OH), summary cerebral small vessel disease (CSVD) score, lacunes, basal ganglia-perivascular spaces (BG-PVS)

CLC Number:

R743

Li Yue, Li Man, Zuo Long, Yang Lei, Qin Wei, Hu Wenli. Relationship between orthostatic hypotension and summary cerebral small vessel disease score[J]. Journal of Capital Medical University, 2024, 45(3): 508-514.

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