Abstract: Objective  To explore the application value of low-temperature plasma bipolar forceps in open thyroid cancer surgery. Methods  The clinical data of 30 patients with differentiated thyroid cancer treated with low-temperature plasma bipolar forceps by our team from May 2021 to October 2024 were retrospectively analyzed. And 30 patients with differentiated thyroid cancer treated with monopolar electrocautery + ultrasonic scalpel were selected as the control group. The surgical procedures for both groups were thyroid lobectomy, isthmus resection + ipsilateral level VI lymph node dissection. The age, gender, body mass index(BMI), tumor TNM stage, operation time, intraoperative blood loss, 48 h postoperative drainage volume, and surgical complications of the two groups were compared. Results  There were no significant differences in age, gender, BMI, and tumor TNM stage between the two groups. The operation time, intraoperative blood loss, 48 h postoperative drainage volume, and the incidence of postoperative transient hypoparathyroidism in the low-temperature plasma bipolar forceps group were significantly less than those in the control group（P<0.05）. There were no occurrences of postoperative subcutaneous hematoma, permanent recurrent laryngeal nerve palsy, and permanent hypoparathyroidism in both groups. Conclusion  In thyroid cancer surgery, low-temperature plasma bipolar forceps can not only achieve fine detailed operations, but also effectively protect the blood supply of the recurrent laryngeal nerve, superior laryngeal nerve, and parathyroid glands. It has less trauma and a faster postoperative recovery, and is worthy of clinical promotion and application.

Key words: thyroid cancer,  low-temperature plasma bipolar forceps,  radiofrequency ablation,  ultrasonic scalpel,  monopolar electrocautery