Journal of Capital Medical University ›› 2025, Vol. 46 ›› Issue (3): 545-552.doi: 10.3969/j.issn.1006-7795.2025.03.020

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Analysis of clinical features and prognosis in pediatric malignant solid tumors of head and neck in single-center

Yang Peiyi1, Duan Chao1, Wang Shengcai2, Jin Mei1, Zhang Dawei1, Fu Libing3, Yu Tong4, Liu Zhikai5, Ma Xiaoli1, Ni Xin2*#, Su Yan1*#   

  1. 1.Medical Oncology Department, Pediatric Oncology Center; National Key Clinical Discipline of Pediatric Oncology；Laboratory for Clinical Medicine，Capital Medical University；Key Laboratory of Major Diseases in Children, Ministry of Education; Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045，China； 2. Department of Otolaryngology Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China; 3.Department of Pathology, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China;  4.Department of Imaging, Beijing Children’s Hospital, Capital Medical University, National Center of Children’s Health, Beijing 100045, China; 5.Department of Radiotherapy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, 100730
  • Received:2024-06-12 Online:2025-06-21 Published:2025-06-25
  • Supported by:
    This work was supported by  National Natural Science Foundation of China (82293660/82293665), National Key R&D Program of China (2023YFC2706100/ 2023YFC2706101).

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Abstract: Objective  To summarize the clinical features and prognosis of children suffered from malignant solid tumors of head and neck. Methods  The clinical data of children with primary malignant solid tumors located in the head and neck was retrospectively analyzed from January 2007 to December 2021 in the Department of Oncology, Beijing Children's Hospital, Capital Medical University, and the clinical features, prognostic factors were summarized. Results  A total of 234 children with malignant solid tumors of head and neck were included, with a male to female ratio of 1∶0.7, aged from 3 months to 17 years and 6 months (median age 51 months). 173 cases (73.9%) were treated with local painless masses. Other symptoms included snoring and facial paralysis. The proportion of rhabdomyosarcoma (RMS) was the highest (145 cases, 62.0%), followed by neuroblastoma (NB) (25 cases, 10.7%), Ewing sarcoma (19 cases, 8.1%), etc. A total of 47 cases (20.1%) had distant metastasis. The patients received surgery, chemotherapy and radiotherapy under the mode of multidisciplinary treatment (MDT). The 3-year and 5-year overall survival(OS) were 80.8% and 75.8%, respectively, and the 3-year and 5-year progression free survival(PFS) were 64.0% and 58.9%, respectively. Tumor survivors had abnormal appearance or facial motor function (49 cases, 41.2%), developmental problems or abnormal tooth loss (18 cases, 15.1%), and other long-term complications that may be related to the tumor or treatment. Conclusion  There are various pathologic types of pediatric head and neck malignant solid tumors, RMS and NB are the most common. Local painless mass was the most common complaint. Distant metastasis is an independent risk factor for the prognosis of head and neck malignant solid tumors. Under the MDT model, the prognosis of malignant solid tumors of the head and neck in our center was generally good. In the treatment of the tumors, the side effects and sequelae should be controlled as small as possible under the premise of long-term survival.

Key words: head and neck, malignant solid tumor, children, clinical features, prognosis

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