Abstract: Objective To compare the antihypertensive efficacies between of Beijing hypotensive No.0 and hydrochlorothiazide(HCTZ) with ambulatory blood pressure monitoring.Methods 57 patients with mild to moderate essential hypertension were divided into two groups randomly.These patients were treated with Beijing hypotensive No.0 or HCTZ for 8 weeks.Clinic blood pressure(CBP),240h ambulatory blood pressure,heart rate and correlative serum biochemics were examined before and after 8 weeks' treatment.Results After treatment,clinic blood pressure and 240h ambulatory blood pressure decreased significantly compared with baseline in two groups.No significant difference was found in heart rate.DBP decreased more in Beijing hypotensive No.0 group than HCTZ group(P≤0.01).The total efficacy rates were 79.3% and 42.9% respectively in Beijing hypotensive No.0 group and HCTZ group(P=0.005).The trough to peak ratios for SBP and DBP were 60.59% and 78.13%,and smoothness index were 0.72±0.27 and 1.09±0.26 respectively in Beijing hypotensive No.0 group,while those of HCTZ were 39.76% and 30.79%,and smoothness index were 0.59±0.29 and 0.40±0.26 respectively.The adverse reactions in two groups were mild.Conclusion Beijing hypotensive No.0 is an efficacy and safe compound antihypertensive drug,which has better antihypertensive effects than that of HCTZ monotherapy.

Key words: Beijing hypotensive No.0, hydrochlorothiazide, hypertension, ambulatory blood pressure