Abstract:

Objective The aim of the study was to assess the clinical value of adenosine stress echocardiography in diagnosis of CAD. Methods Adenosine stress echocardiography(ASE) was performed in 100suspectable CAD patients with infusion of adenosine 140 μg/(kg·min) in 6min. Left ventricular wall motion was recorded during the procedure. Positive criterion was defined as the appearance of wall motion abnormality(WMA). And then among them 64 patients underwent the coronary angiography a week after ASE. Coronary angiography was taken as the golden standard for CAD and comparion of ASE. Results The total sensitivity of this ASE was 68.8% and the total specificity was 81.2% in diagnosis of CAD. Furthermore the sensitivity for detection of myocardial ischemia in one, two and three-vessel CAD sub-groups were 60.6%, 70.0% and 83.3% respectively. Side effects due to adenosine in fusion were always minimal and well tolerated by the patients. Conclusion Adenosine stress echocardiography can be safely performed in suspectable CAD patients with high sensitivity and specificity.

Key words: adenosine, stress echocardiography, wall motion abnormality, coronary heart disease