Polymorphism of Endothelial Nitric Oxide Synthase Gene and Diastolic Blood Pressure in Hypertensive Patients

Abstract

Abstract:

Objective To investigate the relation between the polymorphism of endothelial nitric oxide synthase (eNOS) gene 27 bp variable number of tandem repeats (VNTR) and diastolic blood pressure in hypertensive patients and its possible mechanism. Methods Genotypes of 278 hypertensive patients were determined by polymerase chain reaction (PCR) and agarose gel electrophoresis and gene sequencing was performed at the same time; fasting serum nitric oxide metabolite (NOx) were measured by nitrate reductase. Results The levels of NOx in ab+aa genotype were lower than that in bb genotype(P<0.05). Diastolic blood pressures of ab+aa genotype were significantly higher than that of bb genotype(P<0.05). Conclusion It is suggested that the polymorphism of eNOS gene 27 bp VNTR may be involved in the etiology of the elevation of diastolic blood pressure by reducing NO release of endothelium.

Key words: essential hypertension, nitric oxide synthase, polymorphism

CLC Number:

R544.1

Li Dongbao;Hua Qi;Zou Haiqiang;Chen Biao;Pi Lin;Liu Rongkun. Polymorphism of Endothelial Nitric Oxide Synthase Gene and Diastolic Blood Pressure in Hypertensive Patients[J]. Journal of Capital Medical University, 2005, 26(3): 309-311.

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Polymorphism of Endothelial Nitric Oxide Synthase Gene and Diastolic Blood Pressure in Hypertensive Patients

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