Abstract: Objective To study the change of Syndrome of asthmatic rats at different treatment stage with glucocorticoid(GC) intervention(before withdrawal, during the withdrawal, and after withdrawal). Methods Ninety SD rats were randomized into 3 groups, normal control group, model control group, and GC group. Dexamethasone was injected into asthmatic model of rats and the syndrome was observed at different stage of GC intervention, including weight, armpit temperature, claw temperature and digital photos analysis of the color of claw and tail. Results Before the stage of withdrawing GC, the syndrome of GC group at first was consistent with the characteristics of Yin deficiency syndrome, and later not only had the Yin deficiency syndrome, but also had the trend of Yang deficiency syndrome. During the period of hormone withdrawal, and after the stage of hormone withdrawal, GC group was in line with the syndrome of Yang deficiency. Conclusion This study showed that GC group had the different syndrome characteristics at different stage of the treatment with dexamethasone.

Key words: asthma, glucocorticoid, syndrome