Effect of the Traditional Chinese Medicine Complex 912 Injection on Tissue Oxygenation in the Animal Model of Multiple Organ Dysfunction Syndrome

doi:10.3969/j.issn.1006-7795.2009.06.025

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (6): 834-837.doi: 10.3969/j.issn.1006-7795.2009.06.025

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Effect of the Traditional Chinese Medicine Complex 912 Injection on Tissue Oxygenation in the Animal Model of Multiple Organ Dysfunction Syndrome

REN Tian-hua¹, Wu Yuan-xing¹, REN Ai-ming², ZHANG Shu-wen², WANG Bao-en²

1. Department of Emergency, Beijing Tiantan Hospital, Capital Medical University;2. Department of Infection and Critical Care, Beijing Friend Hospital, Capital Medical University

Received:2009-09-11 Revised:1900-01-01 Online:2009-12-21 Published:2009-12-21

Abstract

Abstract: Objective To study the effect of the traditional Chinese medicine complex 912(Co 912) injection on the tissue oxygenation in the multiple organ dysfunction syndrome(MODS) animal model. Methods Totally 32 one-year-old male piglets with body weight 20~25 Kg were selected for this study. Escherichia coli(E. coli, 17 million/Kg) was injected into right jugular vein, and 5 hours later, all the animals developed MODS, and these MODS model piglets were randomly divided into the following groups: Co 912 injection treatment group; and normal saline control group. The tissue oxygenation-index(arterial oxygen content, CaO₂, oxygen delivery, DO₂, oxygen consumption, VO₂, oxygen delivery index, DO₂I, oxygen consumption index, VO₂I, oxygen extraction rate, O₂ Ext)were determined at 1, 3, 5, 7 h after treatment. Results DO₂ were remarkably better after 5 h or 7 h; VO₂ were remarkably better after 7 h; DO₂I, VO₂I were remarkably better;O₂ Ext was remarkably better after 1 h treatment with Co 912 injection than before treatment. Conclusion The tissue oxygenation-index were remarkably better after treatment with Co 912 injection after 3, 5, 7 h.

Key words: traditional Chinese medicine complex 912, multiple organ dysfunction syndrome, animal model, tissue oxygenation

CLC Number:

R 285.5

REN Tian-hua;Wu Yuan-xing;REN Ai-ming;ZHANG Shu-wen;WANG Bao-en. Effect of the Traditional Chinese Medicine Complex 912 Injection on Tissue Oxygenation in the Animal Model of Multiple Organ Dysfunction Syndrome[J]. Journal of Capital Medical University, 2009, 30(6): 834-837.

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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2009/V30/I6/834

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Effect of the Traditional Chinese Medicine Complex 912 Injection on Tissue Oxygenation in the Animal Model of Multiple Organ Dysfunction Syndrome

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