Abstract: Objective Retrospective study was carried out for perioperative variation of blood glucose and lactate in cardiac surgery patients with cardiopulmonary bypass. Methods From January to December in 2013, 58 adult patients undergoing cardiac surgery with cardiopulmonary bypass were selected and these patients were divided into non - diabetic group and diabetic group according to whether patients have had diabetes mellitus preoperatively. According to the cardiopulmonary bypass time patients were divided into CPB time less than two hours group(group A)and more than two hours group(group B). The perioperative trends of blood glucose and lactate levels were observed, and the related clinical data were analyzed.Results Totally 58 patients CPB time were 59-315[average time:(126.07±50.74)]minutes and aorta cross-clamping time were 35-161[(average time:(67.61±22.95)]minutes, and the automatic heart beat recovery rate is 52%. Blood glucose and lactate levels were increased gradually after induction of anesthesia during operation. The Pearson test shows a positive correlation between blood glucose and lactate. Blood glucose levels rose to the highest level at the end of the surgery and then gradually decreased. Conclusion Effects of cardiopulmonary bypass on perioperative blood glucose in diabetic patients is more obvious, perioperative glycemic control can help lower blood lactate levels. Improving the management of CPB, can help to lower the perioperative blood glucose and lactate levels, thereby reducing complications and improving the prognosis.

Key words: cardiopulmonary bypass, blood glucose, blood lactate