Progress in research on possible role of progesterone receptor membrane component 1(PGRMC1) in the mechanism of breast cancer development

doi:10.3969/j.issn.1006-7795.2015.04.013

Abstract

Abstract:

Breast cancer is one of the most common leading cause of cancers death in women world-wide. But the mechanism of breast cancer development is still unclear. The only placebo-controlled study, the Women's Health Initiative(WHI) demonstrated that breast cancer risk mainly is dependent on the progestogen component since only in the combined estrogen/progestogen arm, but not in the estrogen-only arm this risk was seen to increase the risk. According to this finding, our previous investigation point towards an important role of progesterone receptor membrane component 1(PGRMC1) in hormone related breast cancer risk. This finding got great attention from the related field in the world. An editorial published in the journal Menopause raised the following questions: "Can the increase in breast cancer observed in the estrogen plus progestin arm of the Women's Health Initiative trial be explained by progesterone receptor membrane component 1? Can the PGRMC1 become to be a potential marker in the future? Will the women with high expression of PGRMC1 be breast cancer susceptible people?" We will review the results of related researches.

Key words: progesterone receptor membrane component 1, breast cancer, estrogen receptor, progestogen receptor

CLC Number:

R711

Zhang Ying, Ruan Xiangyan, Alfred O. Mueck. Progress in research on possible role of progesterone receptor membrane component 1(PGRMC1) in the mechanism of breast cancer development[J]. Journal of Capital Medical University, 2015, 36(4): 583-587.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.04.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I4/583

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