Progress in the molecular mechanism of optic nerve damage caused by stress in glaucoma

doi:10.3969/j.issn.1006-7795.2017.01.008

Abstract

Abstract: Glaucoma is a disease characterized by optic nerve damage, visual field defect, and retinal ganglion cells (RGCs) death,which is one of the most common irreversible blinding eye disease in the world. However, the mechanism of the optic nerve damage is not clear. By now, there are no effective clinical neuroprotective treatment methods, especially it was proposed that intervention mode through the RGCs confront against the stress-related damage through molecular methods should be developed. So to explore molecular mechanisms of stress-related damage, such as mechanosensitivity signaling pathways and inflammatory factors of retinal secondary damage mechanism, are becoming hot spots in this field of research. This article summarizes the research progress in the above mentioned fields.

Key words: retinal ganglion cells, tumor necrosis factor-α, integrin

CLC Number:

Yan Fancheng, Wang Ningli. Progress in the molecular mechanism of optic nerve damage caused by stress in glaucoma[J]. Journal of Capital Medical University, 2017, 38(1): 38-41.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.01.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I1/38

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