Arterial stiffness in type 2 diabetic patients and its related factors

doi:10.3969/j.issn.1006-7795.2017.05.020

Abstract

Abstract: Objective To explore type 2 diabetes mellitus and arterial stiffness related factors. Methods A total of 582 cases of patients with type 2 diabetes in our hospital from September 2013 to September 2016 as the research objects of the observation group, and selected 384 healthy people in our hospital were enrolled as the control group. Carotid artery ultrasound and pulse wave velocity of the two groups were checked, test results were observed. Results Observation group of patients with systolic blood pressure (SBP), triglyceride (TG), body mass index (BMI), low density lipoprotein-cholesterol (LDL-C), insulin resistance index, C reactive protein (CRP), homocysteine was higher than that of the control group, high density lipoprotein-cholesterol (HDL-C) was lower than that in the control group, there was statistically significant correlation between the two groups (P<0.05). The observation group patients with carotid artery intima-media thickness(IMT), carotid-femoral pulse wave velocity(CF-PWV) higher than that of the control group (P<0.05), the observation group with the plaque detection rate was 47.59%, the control group with the plaque detection rate was 14.22%, the observation group of bilateral carotid artery plaque detection rate was 33.85%, the control group of bilateral carotid artery plaque detection rate was 5.47%, the two groups had significant difference (P<0.05). Analysis of patients with type 2 diabetes mellitus, Logistic regression analysis showed that age,SBP, LDL-C, homeostasis model assessment of insulin resistance (HOMA-IR), and CRP were the major factors affecting the arterial stiffness. Conclusion In patients with type 2 diabetes and hypertension, hyperlipidemia was significantly higher than that in normal group, carotid artery plaque growth more easily, and large artery elasticity decreased obviously, the influence factors of the stiffness are age, SBP, LDL-C, HOMA-IR and CRP. We should strictly control multiple risk factors in the treatment, improve the treatment effect and improve the quality of life.

Key words: type 2 diabetes, carotid artery intima-media thickness, pulse wave velocity (PWV), related factors

CLC Number:

R587.1

Wang Jundi, Shang Guangyun, He Wei, Wang Hongyu. Arterial stiffness in type 2 diabetic patients and its related factors[J]. Journal of Capital Medical University, 2017, 38(5): 740-743.

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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I5/740

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