Association between subclinical hypothyroidism and lower extremity arterial disease in male patients with diabetes mellitus

doi:10.3969/j.issn.1006-7795.2018.04.008

Abstract

Abstract: Objective To investigate the relationship between subclinical hypothyroidism (SCH) and lower extremity arterial disease(LEAD) in patients with type 2 diabetes. Methods Totally 746 patients with type 2 diabetes hospitalized in the Department of Endocrinology of Beijing Tongren Hospital, Capital Medical University were selected. The thyroid function and ankle brachial index (ABI)were examined in all patients. And then diabetic patients were divided into two groups with and without LEAD according to ABI. The basic situation, biochemical indexes and SCH prevalence rate of the two groups were compared. Univariate and multivariate Logistic regression analysis was used to analyze the risk factors of diabetic LEAD. Results 117 cases combined with SCH and the prevalence rate among women was significantly higher than that among men(P<0.05)in these 746 patients with type 2 diabetes. The level of thyroid stimulating hormone (TSH) and the prevalence of SCH in the LEAD group were higher than those in the control group. Logistic regression analysis showed that age (OR, 1.055,95% CI:1.031-1.078, P<0.001), SCH (OR, 2.162, 95% CI:1.383-3.379, P=0.001), smoking(OR, 2.129,95% CI:1.352-3.355, P=0.001), systolic blood pressure (OR, 1.014,95% CI:1.004-1.023, P=0.005), low density lipoprotein (OR, 1.189,95% CI:1.026-1.378, P=0.021)was positively correlated with LEAD, and total glomerular filtration rate (OR, 0.984,95% CI:0. 974-0.995, P=0.003)was negatively correlated with LEAD. In male patients, SCH had a more significant effect on LEAD (OR, 3.747,95% CI:1.940-7.239, P<0.001), but no correlation was found in female patients. Conclusion The results suggested a closed association between SCH and LEAD in male patients with type 2 diabetes mellitus.

Key words: subclinical hypothyroidism, type 2 diabetes, lower extremity arterial disease, ankle brachial index

CLC Number:

Zhang Lin, Yuan Mingxia, Yang Guangran, Liu Wei, Xie Rongrong, Du Yanfang, Yang Jinkui. Association between subclinical hypothyroidism and lower extremity arterial disease in male patients with diabetes mellitus[J]. Journal of Capital Medical University, 2018, 39(4): 522-526.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.04.008

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I4/522

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