Augmentation of rTMS in the treatment of refractory schizophrenia

doi:10.3969/j.issn.1006-7795.2018.05.004

Abstract

Abstract: Objective To explore the augmentation effect of repetitive transcranial magnetic stimulation in the treatment of refractory schizophrenia.Method< Fifty schizophrenia patients were included and were divided into low frequency (1Hz) treatment group of 26 cases and high frequency (10 Hz) treatment group of 24 cases. Each treatment group was further randomly divided into an experimental group and a control group. This study is a randomized, double-blind, controlled study, the control group was subjected to pseudo-stimulation. The clinical symptoms of the two groups of patients were evaluated and the therapeutic effects of the two groups were compared.Results A total of 53 patients who met the inclusion criteria were enrolled, and a total of 50 patients completed the study.After t test and χ² test, there was no significant difference in the basic data between the two groups.Low frequency treatment:there was no statistically significant difference between the groups. High frequency treatment:There was no statistically significant difference between the groups There was a time difference in the scale scores for the 4th weekend for all patients in the group. High frequency treatment:There was no statistically significant difference between the groups, Three patients with 1Hz experimental group and two patients with 10 Hz experimental group complained of headache and numbness during the first treatment, other patients are not uncomfortable.Conclusion Repetitive transcranial magnetic stimulation combined with drug therapy has not been found to have an effect on positive and negative symptoms in patients with refractory schizophrenia.

Key words: repetitive transcranial magnetic stimulation, schizophrenia, augmentation

CLC Number:

R749.3

Sun Congcong, Zhou Danna, Ning Fangping, Ma Liang, Yan Liqiong, Ren Yanping, Ma Xin. Augmentation of rTMS in the treatment of refractory schizophrenia[J]. Journal of Capital Medical University, 2018, 39(5): 641-645.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.05.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I5/641

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