Correlation between alpha activity and cognitive in resting electroencephalogram of schizophrenia

doi:10.3969/j.issn.1006-7795.2021.01.020

Abstract

Abstract: Objective To explore the correlation between alpha oscillation and cognitive in resting electroencephalogram (EEG) of schizophrenia. Methods Participants are 22 schizophrenia patients (SCH) and 23 matched healthy controls (HC). All participants were required to perform the MATRICS Consensus Cognitive Battery (MCCB) for cognitive evaluation, and electrophysiology indexes were recorded by EEG recording system. Comparisons were made between two groups in alpha relative power on the left frontal area (F3, F7), the right side of the frontal area (F4, F8), the left side of the central region (T3, C3), the right side of the central (T4, C4), left posterior brain areas (T5, P3, O1), right posterior brain areas (T6, P4, O2), and the Fz, CPz, Pz, Oz sites. Results In addition to the social cognitive dimension, scores of the schizophrenia group in all other dimensions of MCCB test were significantly lower than the HC group (All P<0.001). Compared to HC, the SCH group exhibited significantly lower global alpha activity (P<0.05) under closed eyes and exhibited significantly lower global alpha activity on posterior brain areas and CPz, Pz and Oz electrodes (P<0.05) under open eyes. In SCH group, the MCCB scores, information processing speed scores, speech learning and memory scores, and reasoning and problem solving scores positively related to the global relative alpha activity under closed eyes, except the first three dimensions under open eyes. Conclusions There're multidimensional damages of the cognitive level in schizophrenic. Under the resting-state alpha oscillation is positively related with the information processing speed, verbal learning and memory, reasoning and problem solving. Therefore, the resting-state alpha oscillation could be a biological indicator of the cognitive level in schizophrenic.

Key words: schizophrenia, resting state, resting electroencephalogram (EEG), alpha, cognitive

CLC Number:

R749.3

Sha Sha, Zhao Xixi, Han Chuanliang, Peng Xing, Zhang Pei, Dong Wen, Yin Jingjing, Wang Changming. Correlation between alpha activity and cognitive in resting electroencephalogram of schizophrenia[J]. Journal of Capital Medical University, 2021, 42(1): 117-124.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.01.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I1/117

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