Preparation of a novel iridium(Ⅲ) complex probe for sensing of copper ion and hydrogen sulfide in sequence

doi:10.3969/j.issn.1006-7795.2021.01.010

Journal of Capital Medical University ›› 2021, Vol. 42 ›› Issue (1): 58-65.doi: 10.3969/j.issn.1006-7795.2021.01.010

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Preparation of a novel iridium(Ⅲ) complex probe for sensing of copper ion and hydrogen sulfide in sequence

Pang Qidan, Wang Tianran, Xiao Nao^*

Department of Chemical Biology, School of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China

Received:2020-09-01 Online:2021-02-21 Published:2021-02-02
Contact: ^*E-mail:xiaonao@ccmu.edu.cn
Supported by:
Natural Science Foundation of Beijing (2174069), Scientific Research Common Program of Beijing Municipal Commission of Education (KM201510025007), Scientific Research Cultivating Fund of Capital Medical University (1200020248).

Abstract

Abstract: Objective To synthesis a new water-soluble iridium complex Ir-cyc and explore the sensing properties of Ir-cyc towards Cu²⁺ and H₂S in sequence with fluorescence spectra. Methods Iridium complex [Ir(ppy)₂Cl]₂ was prepared from 2-phenylpyridine (ppy) and iridium trichloride (IrCl₃); the ligand Phen-Br was synthesized from 5-amino-o-phenanthroline and 2-bromoacetyl bromide by nucleophilic substitution; the bromine-functionalized iridium complex Ir-Br was obtained by chelation reaction of [Ir(ppy)₂Cl]₂ and Phen-Br; Ir-Br was further nucleophilically substituted with cyc to prepare the probe molecule Ir-cyc. Results The structures of the synthesized intermediates and final iridium complex were determined by mass spectrometry. The basic photophysical properties of the probe Ir-cyc were characterized by fluorescence spectroscopy and UV-Vis spectroscopy. The fluorescence spectral changes revealed that the probe Ir-cyc could detect Cu²⁺ and H₂S in sequence. Conclusion A novel iridium complex of probe Ir-cyc was prepared by classical chelation and nucleophilic substitution reactions, which could recognize Cu²⁺ and H₂S sequentially in aqueous solution and has potential application in environmental monitoring and biological sample analysis.

Key words: iridium complex, fluorescent probe, Cu²⁺ ion, hydrogen sulfide, MS analysis

CLC Number:

O654.9

Pang Qidan, Wang Tianran, Xiao Nao. Preparation of a novel iridium(Ⅲ) complex probe for sensing of copper ion and hydrogen sulfide in sequence[J]. Journal of Capital Medical University, 2021, 42(1): 58-65.

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Preparation of a novel iridium(Ⅲ) complex probe for sensing of copper ion and hydrogen sulfide in sequence

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