A view of sulforaphane interference with microtubules and mitochondrial kinetics in anti-cancer mechanisms

doi:10.3969/j.issn.1006-7795.2023.03.001

Abstract

Abstract: Sulforaphanes (SFNs) are naturally active substances extracted from cruciferous plants such as broccoli, cabbage, and carrot. SFNs metabolize to produce sulforaphane N-acetylcysteine (SFN-NAC), sulforaphane cysteine (SFN-Cys) and sulforaphane glutathione (SFN-GSH). Sulforaphane inhibits the growth of many tumor cells and has low toxicity to normal tissues, but its circulating half-life is only 2 h. However, either SFN-NAC or SFN-Cys has a longer half-life in circulation. After injected into mice, SFN-NAC and SFN-Cys are excreted through urine after 72 h. For more than ten years, we have systematically studied the anti-cancer mechanisms of SFN and their metabolites (SFNs). Except for their different half-lives, the anti-cancer mechanisms of SFNs are highly consistent. We found that SFNs are a class of microtubule inhibitors that cause tumor cell growth inhibition and apoptosis by interfering with the structure of microtubules, regulating microtubule dynamic balance, and inhibiting mitochondrial function.

Key words: sulforaphane, microtubule, autophagy, apoptosis, protein homeostasis

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2023.03.001

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2023/V44/I3/363

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