Abstract: Angioarchiteture of the CNS were visualized with peroxidase cytochemistry in rat.This technique can successfully demonstrat that the endogenous peroxidase activity of red cells and granular leukocytes(especilly polymorphonuclear and eosinophilic)were excellent mar-kers for revealing CNS blood vessels at the light microscopic level when 3,3′-diaminobenzi-dine (DAB), benzidine dihydrochloride (BDHC), O-dianisidine (O-D) and tetramethyl-benidine(TMB) were used as chromogen.The four peroxidase cytochemical approches are useful for visualizing CNS microvasculature in nomal laboratory animals; the four approches have potential application to cerebrovascular studies of stroke, trauma, neoplasia and intra-cerebral grafts.

Key words: peroxidase, benzidine, central nervous system, angioarchtecture