The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit

Journal of Capital Medical University ›› 1992, Vol. 13 ›› Issue (3): 171-176.

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The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit

Yang Tao¹, Lin Guifen¹, Wang Keda¹, Jiang Ming¹, Tang Yu¹, Chen Guijun², Li Wushan², Jin Jingshan²

1. Department of Pharmacology, Capital Institute of Medicine;2. Department of Biochemistry, Beijing Institute of China Traditional Medicine

Received:1991-06-01 Revised:1900-01-01 Online:1992-07-15 Published:1992-07-15

Abstract

Abstract: This paper reported the effect of ilexonine A (IA) administration in vitro on rabbit platelet aggregation induced by arachidonic acid (AA) in vitro, and the change of malon-dialdehyde (MDA)level in aggregated platelet suspension. The results showed that IA could inhibit platelet aggregation and MDA formation induced by AA. A certain correlation was shown, Between inhibiting rate of aggregation and decrease of MDA level, suggesting the antiplatelet effect of IA might be related to its inhibiton of the formation of MDA. According to MDA is the parameter of thromboxane A₂ (TXA₂) synthesis (TXA₂ is an active metabo-lite of AA during platelet activation), we hypothesiz that IA might interfere with the TXA₂, formation and it may be the mechanism of the antiplatelet effect of ilexonine A.

Key words: ilexonine A, platelet aggregation, MDA, TXA₂

CLC Number:

R285.5

Yang Tao;Lin Guifen;Wang Keda;Jiang Ming;Tang Yu;Chen Guijun;Li Wushan;Jin Jingshan. The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit[J]. Journal of Capital Medical University, 1992, 13(3): 171-176.

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The Effect of Ilexonine a Administration in Vitro on Platelet Aggregation and Malondialdehyde Formation Induced by Arachidonic Acid in Rabbit

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