Abstract:

KA8 peptide is a C-terminal octapeptide(30～37)of oxyntomodulin 1～37. We previously reported that it could inhibit gastric acid secretion of rat induced by pentagastrin, cold-restraint and intracisteral TRH obviously. In our experiment ,KA8 peptide was injected to rats at a dose of 30 μg/kg body weight or 60 μg/kg body weight before 1 mL absolute ethanol was given to the animals through a gastric tube. The results showed that KA8 peptide could decrease ethanol-induced gastric erosion significantly, compared with control(P<0.01). It suggests that KA8 peptide could have cytoprotective effect on gastric mucosa, and it might be beneficial in the treatment of a variety of diseases in which gastric mucosal injury is present.

Key words: KA8 peptide, ethanol, gastric mucosal erosion, cytoprotective effect