Detection of Lymphocyte Subsets in Peripheral Blood of Patients with Hepatitis C

Abstract

Abstract: T cell subsets in peripheral blood of 35 chronic patients with hepatitis C have been investigated through monoclonal antibody and APAAP assay. The results showed that the percentage of OKT3⁺ cells in patient group with hepatitis C had no difference and OKT₄⁺,OKT₈⁺ cells and OKT₄/OKT₈ ratio were lower than that of the control group.The percentage of OKT₄⁺ cells and OKT₄/OKT₈ ratio in HBsAg negative patient group with hepatitis C were significantly lower than that of the control group. No difference was observed in the percentage of OKT₈ cells. The percentages of OKT₄⁺,OKT₈⁺cells in HBsAg positive patient group with hepatitis C were significantly lower in comparison with control group and chronic active patient group with hepatitis B, but the OKT₄/OKT₈ ratio showed no difference. The percentage of OKT₈⁺ cells was significantly lower as compared with HBsAg negative patient group with hepatitis C. These results indicated that T cell subsets in peripheral blood in patients with hepatitis C were obviously out of balance and the percentage of OKT₈⁺ cells was significantly lower in hepatitis C patients co-infected with HBV.

Key words: hepetitis C, hepatitis B, T cell subsets, monoclonal antibody

CLC Number:

R512.6

Song Xiaoping;Chen Zugui;Min Fuyuan;Leng Qiang;Sun Limei;Wu Hao;Lin Xiuyu;Wang Juntao. Detection of Lymphocyte Subsets in Peripheral Blood of Patients with Hepatitis C[J]. Journal of Capital Medical University, 1994, 15(2): 119-122.

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Detection of Lymphocyte Subsets in Peripheral Blood of Patients with Hepatitis C

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