Difluoromethyl Ornithine Reduced Delayed Neuronal Death in the Rat Hippocampus Following Transient Brain Ischemia

Abstract

Abstract: Delayed neuronal death occured in the rat hippocampus following brief ischemia.We study and evaluate the effects of difluoromethyl ornithine (DFMO).ODC inhibitor, on the survival of neurons in the hippocampal CA₁ subfield.The pyramidal cell density in the CA₁ region is used as index of the effects.The results of experiment showed that DFMO has considerably reduced neuron loss in the CA₁ region.The favorabal effects are obviously dose-dependent and administration time-dependent.Furthermore, the results suggest that polyamine and ODC might play an importent role in the genesis of the delayed neuronal death following transient cerebral ischemia.

Key words: cerebral ischemia, cell survival, hippocampus, ornithine decarboxylase

CLC Number:

R338.2

Hu Ying'an;Zhang Maoxian. Difluoromethyl Ornithine Reduced Delayed Neuronal Death in the Rat Hippocampus Following Transient Brain Ischemia[J]. Journal of Capital Medical University, 1996, 17(4): 255-258.

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Difluoromethyl Ornithine Reduced Delayed Neuronal Death in the Rat Hippocampus Following Transient Brain Ischemia

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