Effects of Baicalin on Contraction of Rat Aortic Strips

Journal of Capital Medical University ›› 1997, Vol. 18 ›› Issue (2): 114-117.

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Effects of Baicalin on Contraction of Rat Aortic Strips

Hei Ailian, Sun Songsan

Department of Pharmacology, Capital University of Medical Sciences

Received:1996-07-19 Revised:1900-01-01 Online:1997-04-15 Published:1997-04-15

Abstract

Abstract: Baicalin(Bai)and verapamil(Ver)inhibited the contractions of isolated rat aortic strips evoked by norepinephrine(NE),KCl and CaCl₂. They also caused the dose response curves to shift rightward and depressed the maximal response,but Bai was less potent than Ver. Both Bai and Ver inhibited the fast contraction responses evoked by NEin Ca²⁺ free medium and slow Ca²⁺ dependent component on contraction. The results indicated that Bai like Ver, may be a calcium antagonist.

Key words: baicalin, verapamil, norepinephrine, KCl, CaCl₂, aorta

CLC Number:

R932.5

Hei Ailian;Sun Songsan . Effects of Baicalin on Contraction of Rat Aortic Strips[J]. Journal of Capital Medical University, 1997, 18(2): 114-117.

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Effects of Baicalin on Contraction of Rat Aortic Strips

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