Abstract: We evaluated oxidative modification of low-density lipoprotein (LDL) and antioxidants in 59 children with adiposis simplex and 75 control subjects to explore the mechanism of atherosclerosis in adiposis simplex . It was found that blood oxidized LDL (ox-LDL) was higher and vitamin Elevel was lower in adiposis than that in controls. Serum total antioxidant ability had no significant difference between the two groups. Both linear correlation and mul factor stepwise regression analysis revealed that Rohler index was positively correlated with ox-LDL, and was negatively correlated with vitamin E. The results suggested that oxidative modification of LDL was the basis of atherosclerosis in adiposis simplex. Oxidative modification of LDLwas related to lower vitamin Eand higher triglyceride levels. Replenishing vitamin Eand lowering triglyceride should be important measures for preventing atherosclerosis in children of adiposis simplex.

Key words: adiposis, low-density lipoprotein, oxidative modification, vitamin E