Journal of Capital Medical University ›› 1998, Vol. 19 ›› Issue (1): 19-22.

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Determination and Effects of the Cholesterol Biosynthetic Inhibitor Produced by Monascus

Yu Jin, Zhu Changren   

  1. Department of Pathology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences
  • Received:1997-04-06 Revised:1900-01-01 Online:1998-01-15 Published:1998-01-15

Abstract: Atherosclerotic rabbits were treated by administrating Monascus. Changes of atherosclerosis and hyperlipidemia were observed. The experiments confirmed that Monascus may reduce serum cholesterol concentration in hypercholesterolemic rabbits and cease from progress of atherosclerosis. The metabolite of Monascus was determined by using the thin layer chromatographic qualitative analysis method and the HPLC quantitative analysis method. The results showed that lovastatin, an inhibitor of biosythesis of cholesterol, was produced by Monascus.

Key words: Monascus, atherosclerosis, lovastatin

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