Effects of citrus and pinellia on the levels of PI3K-Akt pathway, SOD, MDA, SA-sap-gal in atherosclerosis mice

doi:10.3969/j.issn.1006-7795.2018.06.003

Abstract

Abstract: Objective To explore the mechanism of treating atherosclerosis with Citrus and Pinellia. Methods A total of 50 Klotho knockout mice were randomly divided into the normal group, the model group and the treatment group (high, medium and low dose group). The pathological changes of carotid artery were observed with HE staining. The plasma of malondialdehyde(mDA), superoxide dismutase(SOD), senescence-associated beta-galactosidas (SA-β-gal) and the expression of PI3K and p-Akt was examined with immunohistochemistry. Results Compared with the model group, the arterial intima in the Citrus and Pinellia group showed mild hyperplasia. Compared with the control group, the level of SOD increased significantly (P<0.01), while the content of MDA and SA-β-gal decreased significantly (P<0.01). Compared with the model group, the decrease level of PI3K in the high and medium-dose treatment groups was statistically significant (P<0.01), P-Akt expression in the treated group was significantly lower than that in the model group, and the difference was statistically significant (P<0.01). Conclusion Citrus and Pinellia may regulate the levels of SOD, MDA and SA-β-gal through PI3K and p-Akt pathway, to delay senescence and treat atherosclerosis.

Key words: Citrus, Pinellia, aging, atherosclerosis, PI3K, p-Akt

CLC Number:

R285.5

Sun Yanan, Huang Xiaobo, Liang Wei, Chen Wenqiang. Effects of citrus and pinellia on the levels of PI3K-Akt pathway, SOD, MDA, SA-sap-gal in atherosclerosis mice[J]. Journal of Capital Medical University, 2018, 39(6): 805-809.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.06.003

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I6/805

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