Journal of Capital Medical University ›› 1998, Vol. 19 ›› Issue (3): 225-227.

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The Delayed Antiarrhythmic Effects of Femoral Artery Ischemic Preconditioning in Rats

He Feng1, Wang Jiarui1, Lu Lingqiao2, Zhu Yingfen2, Zhang Like2   

  1. 1. Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Pathophysiology, Capital University of Medical Sciences
  • Received:1997-06-30 Revised:1900-01-01 Online:1998-07-15 Published:1998-07-15

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Abstract: The delayed antiarrythmic effects of femoral artery ischemic preconditioning(FIP)in rats were observed. Results: During the cardiac ischemia, the incidences of VT,VF were significantly reduced and the accumulative total periods of VT,VF were significantly shortened in group FIP compared with in group NIP(P<0.01). The incidences of reperfusion induced VT,VF and the mortality in group FIP were not significantly reduced from NIP group(P=NS). But in group FIP 24 h, the incidences of reperfusion induced VT,VF were significantly reduced and the mortality was significantly reduced from NIP group of 50% to 0%(P<0.05). The results suggest that the protective effects of FIP against ischemia and reperfusion induced arrhythmias in rats are obvious. The delayed antiarrythmic effects of FIP are more effective than the early ones and reducing the incidence of reperfusion induced IVF and increasing the survival are their dominant effects.

Key words: femoral artery, ischemic preconditioning, arrythmias

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