The Relationship between Insertion/deletion Polymorphism of Angiotension-converting Enzyme Gene and Coronary Heart Disease

Abstract

Abstract: Insertion/deletion(I/D)polymorphism of the ACE gene was detected by polymerase chain reaction(PCR)in a study of 100 control subject and 95 patients with coronary heart disease(CHD), and was campared with serum ACE level and CHD morbidity in Beijing population and prodisposing factors. Results: The frenquencies of D allele(0.54)and DD genotype(0.35)were higher among the CHD group than among the control subjects(0.35,0.13,both P<0.01). Conclution: Deletion polymorphism of the ACE gene might be an important risk factor for CHD in Chinese population.

Key words: angiotension coverting enzyme, gene polymorphism, PCR, coronary heart disease

CLC Number:

R541.4

Gu Haitong;Zhang Husheng;Wang Yong;Jiang Yanfang . The Relationship between Insertion/deletion Polymorphism of Angiotension-converting Enzyme Gene and Coronary Heart Disease[J]. Journal of Capital Medical University, 1998, 19(3): 228-230.

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The Relationship between Insertion/deletion Polymorphism of Angiotension-converting Enzyme Gene and Coronary Heart Disease

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