A Study on p53 Protein Expression in Touch-Preperations of the Lung Cancer by Immunohistochemistry Method

Journal of Capital Medical University ›› 1998, Vol. 19 ›› Issue (4): 309-311.

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A Study on p53 Protein Expression in Touch-Preperations of the Lung Cancer by Immunohistochemistry Method

Yan Tiansheng¹, Zhang Dawei², Wu Min³, Wang Xiuqin³

1. Department of Thoracic Surgery, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences;2. Dept. of Thoracic Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College;3. Dept. of Cell Biology and National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences,Peking Union Medical College

Received:1998-01-11 Revised:1900-01-01 Online:1998-10-15 Published:1998-10-15

Abstract

Abstract:

To make the method searching the p53 expression of lung cancer usable wildely in clinic units , the author studied the p53 protein expression of 33 cases lung cancer resected surgically both with the fresh tissue touch preparations and with frozen tissue specimens by using immunohistochemistry ABC method. The results showed that the p53 positive rate of touch preparations and frozen tissue specimens was 60.60% and 63.64%, respectively. The statistic analysis to the results of two groups displayed very much remarkable relativity(P<0.001), but the no significant discrepancy(P>0.05). The conclusion is that the method of the touch preparations specimens has the convenient, accurate and reliable characteristis for testing p53 protein expression and needs not to do the common pathological specimens. There is some prospects for clinic use in the future.

Key words: lung cancer, p53 protein, immunohistochemistry

CLC Number:

Yan Tiansheng;Zhang Dawei;Wu Min;Wang Xiuqin. A Study on p53 Protein Expression in Touch-Preperations of the Lung Cancer by Immunohistochemistry Method[J]. Journal of Capital Medical University, 1998, 19(4): 309-311.

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A Study on p53 Protein Expression in Touch-Preperations of the Lung Cancer by Immunohistochemistry Method

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