Abstract:

Protective effects of baicalin on myocardium ischemia-repurfusion injury were studied in rats. Wistar rats were divided into 5 groups: pseudo operation; ischemia reperfusion operation; ischemia-reperfusion with baicalin 20 mg/kg and 80 mg/kg; ischemic-reperfusion with Verapamil 1 mg/kg. The results showed that baicalin reduced frequency of arrhythmia, contents of CK and MDA, and increased activities of SOD and GSH-PX. The results suggest that baicalin possesses protective effects on myocardium ischemia reperfusion injury in rats and its mechanism is related to inhibition of lipid peroxidation.

Key words: baicalin, myocardial ischemia reperfusion, myocardial injury, lipid peroxides, supero xide dismutase