Abstract: To study the different medication of traumatic brain edema in rats, 54 rats in which the models of traumatic brain edema were induced by Feeney's extradural impact were divided into six groups randomly. Different groups were treated with special drugs and different dosages. The study observed the changes of the blood-brain barrier with Evans Blue and the water content of the brain after the brain injury in rats. Injury areas were observed by pathological techniques in the experiment. The decreases of injury area and the water content of the brain after the brain injury were the most evident in the groups that were treated with large-dosage mannitol. It was proved by the pathological observation that brain injury was the lightest in the asme groups. Curative effect of little dosage mannitol and frusemin used together can last for a long time. Mannitol is the most effective drug in treating acute traumatic brain edema , but little dosage mannitol and frusemin used together is the best choice after mannitol was used solely five to six times.

Key words: brain injury, brain edema, therapy