Abstract: To investigate the biocompatibility of dialyzers compared 12 patients on long-term haemodialysis treated with curprophane and polysulphone dialyzers in a cross-over design. During the dialysis TAT, PAP and D-dimer were measured by ELISA. After the dialysis the membranes were observed with scanning electron-microscope. During haemodialysis TAT, PAP and D-dimer with two kinds of dialyzers were higher than before the dialysis. In comparion with cuprophan, concentrations of coagulation and fibrinolysiss parameters in ploysulphone membrane were low. The result indicates that as far as coagulation and fibrinolysis are concerned, the biocompatibility of polysulphone membrane is better than that of the cuprophone one. Biocompatibility dialyzer should be selected to decrease the appearance of the long-term hemodialysis-related complication.

Key words: haemodialysis, dialyzer membrane, TAT, PAP, D-dimer