Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (1): 6-9.

• 基础研究 • Previous Articles     Next Articles

Gene Cloning of Human Aromatic Amino Acid Decarboxylase

Zhang Zhi, Zhao Huanying, Duan Deyi, Xu Qunyuan, Yang Hui   

  1. Beijing Institute for Neuroscience and Beijing Center for Neural Regeneration and Repairing, Capital University of Medical Sciences
  • Received:2001-05-28 Revised:1900-01-01 Online:2002-01-15 Published:2002-01-15

Abstract: The objective of the study was to obtain the gene of human Aromatic amino acid decarboxylase(AADC), which would be used in gene therapy for Parkinson disease. The fragment of AADC was obtained by RT-PCR from the substantia nigra of humen fetus, and then cloned into the pGEM-T vector and sequenced. Compared with the sequence deposited in GenBank, the sequence of gene cloned in present study is correct.

Key words: aromatic amino acid decarboxylase, Parkinson disease, gene therapy

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