Journal of Capital Medical University ›› 2002, Vol. 23 ›› Issue (2): 139-141.

• 临床研究 • Previous Articles     Next Articles

Effects of Salt on Levels of Angiotensin Ⅱ in Plasma and Tissues

Xu Xiuying1, Huang Yan2, Wang Jiarui2   

  1. 1. Department of Cardiology, Beijing Tiantan Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Cardiology, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences
  • Received:2001-05-14 Revised:1900-01-01 Online:2002-04-15 Published:2002-04-15

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Abstract: To investigate the effects of salt on the levels of angiotensin Ⅱ(AngⅡ)in plasma and tissues in spontaneously hypertensive rat(SHR), twenty 8-week-old male SHRs were divided into experimental and control groups(n=10). They were given 2% NaCl and distilled water respectively for 6 weeks. Plasma renin activity(PRA)and AngⅡ levels were measured by radioimmunoassays. Results showed that PRA in experimental group was decreased(1.13±0.72)ng/(mL·h)vs(1.94±0.96)ng/(mL·h, (P<0.05)and plasma AngⅡ had a slight decrease but no significant difference 〔(89.4±1.4)ng/L vs(111.6± 1.3)ng/L, P>0.05〕 compared with the control. AngⅡ levels increased in heart and artery in the experimental group 〔(227.1±1.1)pg/g vs(151.4±1.1)pg/g, (P<0.01,(57.1±1.5)pg/g vs(30.7±2.0)pg/g, (P<0.05〕, AngⅡ levels in kidney appeared to be no significant difference between two groups. The experiment indicates that circulatory and tissue renin-angiotension-system response to salt was different in SHR.

Key words: salt|renin-angiotension-system|spontaneously hypertensive rat

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