Effect of AGEs and Concentration of Glucose on Proliferation of Vascular Endothelial Cells Cultured in Vitro

Journal of Capital Medical University ›› 2003, Vol. 24 ›› Issue (2): 133-134.

• 论著·临床研究 • Previous Articles Next Articles

Effect of AGEs and Concentration of Glucose on Proliferation of Vascular Endothelial Cells Cultured in Vitro

Chen Hui¹, Tian Mi², Han Caihe³, Zhang Jing¹, Wu Qing¹

1. China Rehabilitation Research Center, Capital University of Medical Sciences;2. Department of Experiment Center, Capital University of Medical Sciences;3. Institute of Geriatrics, Ministry of Health

Received:2002-05-20 Revised:1900-01-01 Online:2003-04-15 Published:2003-04-15

Abstract

Abstract: The objective was to study the effect of AGEs on proliferation of endothelial cells of cord vein from newborn. ³H-TdR incoporation rate of cultured cells was used as parameter for cell proliferation and VitEaffected proliferation of endothelial cells. After two hours of endothelial cells of cord vein from newborn, 11 mmol/Lglucose, AGEs (5 mg/L), VitEand 30 mmol/Lglucose were cultured to test ³H-TdR incoporation rate. The ³H-TdR incorporation rates were 4.69 times (P<0.01), 2.15 times (P<0.05) and 1.46 times (P<0.05) higher than the control group respectively. High glucose and AGEs stimulate proliferation of endothelial cells. Especially, high glucose and AGEs are in cultured cells. At same time VitE could inhibit proliferation of endothelial cells.

Key words: AGEs, proliferation of endothelial cells of cord vein from newborn, different glucose

CLC Number:

R587.1

Chen Hui;Tian Mi;Han Caihe;Zhang Jing;Wu Qing. Effect of AGEs and Concentration of Glucose on Proliferation of Vascular Endothelial Cells Cultured in Vitro[J]. Journal of Capital Medical University, 2003, 24(2): 133-134.

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Effect of AGEs and Concentration of Glucose on Proliferation of Vascular Endothelial Cells Cultured in Vitro

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