Effect of Id4 on K562 Cell Proliferation

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (2): 150-153.

• 论著·基础研究 • Previous Articles Next Articles

Effect of Id4 on K562 Cell Proliferation

Liu Xin¹, Zeng Shaoju², Wang Yongchao², Zhang Jinfeng¹

1. Department of Cell Biology and Genetics, Capital University of Medical Sciences;2. The Key Laborabory of Cell Proliferation and Regulation Biology, Bejing Normol University

Received:2003-12-09 Revised:1900-01-01 Online:2004-04-15 Published:2004-04-15

Abstract

Abstract: In order to study the actions of Id4 in cell proliferation of blood cell, antisense Id4 gene was transfected into human erythroleukemia cell line K562, Id4 gene.Anti-sense Id4 brought about poor growth traits, long multiplication time in comparison with the control group. By using of western-blot, the related protein CDK4, CyclinD1 and RB expressions changed obviously. The results show that Id4 plays an important role in cell proliferation of blood cells.

Key words: Id4 gene, cell proliferation, CDK4, CyclinD

CLC Number:

Liu Xin;Zeng Shaoju;Wang Yongchao;Zhang Jinfeng. Effect of Id4 on K562 Cell Proliferation[J]. Journal of Capital Medical University, 2004, 25(2): 150-153.

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Effect of Id4 on K562 Cell Proliferation

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