Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (2): 227-229.

• 论著·临床研究 • Previous Articles     Next Articles

Expression of CD117 in Acute Promyelocytic Leukemia

Wan Suigui1, Xu Juan1, Gong Wenyu2, Su Xuejing1, Tian Ding1   

  1. 1. Department of Hematology, Xuanwu Hospital, Affiliate of Capital University of Medical Sciences;2. Department of Hematology, Beijing Children Hospital
  • Received:2003-04-06 Revised:1900-01-01 Online:2004-04-15 Published:2004-04-15

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Abstract: The aim was to investigate the expression of CD117 in acute promyelocytic leukemia and its significance. The expression of CD117 was detected using three-color flow cytometry. CD117 was positive in 19/22 of patients with acute promyelocytic leukemia(APL), in 2/2 and 18/21 of patients with AML-M1 and AML-M2 respectively. Among nineteen APL patients with CD117, eighteen were CD34- and HLA-DR-. Only one patient was partial HLA-DR+. There was high level expression of CD117 in acute promyelocytic leukemia. Minimal residual disease of APL can be detected using multi-color flow cytometry to analyze the expression of CD117, CD34 and HLA-DR.

Key words: acute promyelocytic leukemia, CD117, immunophenotype, minimal residual disease

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