Abstract: The aim was to test the hypothesis that endothelial dysfunction is already evident in normoalbuminuric with type 2 diabetes.Previous studies have shown that the development of microalbuminuria is associated with the onset of endothelial dysfunction in individuals with type 2 diabetes.Plasma soluble intercellular adhesion molecule(sICAM-1), soluble vascular cell adhesion molecule(sVCAM-1), vWF were measured by ELISA in 28 healthy control subjects(groupⅠ), 57 normoalbuminuria individuals with type 2 diabetes(groupⅡ), and 25 microalbuminuria individuals with type 2 diabetes(groupⅢ).Plasma sICAM-1 levels were significantly higher in the groupⅡ and groupⅢ than that in the groupⅠ(P<0.05).In contrast plasma sVCAM-1 and vWF levels were elevated only in the groupⅢ compared with groupⅡ and groupⅠ(P<0.05).Correlated analysis showed a significant positive correlation between sICAM-1 and blood pressure,triglyceride, vWF, sVCAM-1.The results suggest that plasma sICAM-1 levels might be implicated in the development of diabetic vasculopathy, and could predict the onset of endothelial dysfunction instead of plasma vWF levels.The measurement of plasma sICAM-1 levels in type 2 diabetic patients may be clinically useful for early discovering of endothelial dysfunction.

Key words: type 2 diabetic, microalbuminuria, CAMs