Abstract: The objective was to study the variation tendency of bilirubin concentration with plasma exchange dosage. The time-measurement method was used to obtain the concentration of bilirubin in plasma from severe hepatitis patients. Theoretically, On the basis of principle of plasma exchange, a two-compartment model of plasma exchange was established, and the relationship between the bilirubin concentration and the dosage of plasma exchange was derivated. Results: The difference between the theoretical and experimental values were quite small, Which illustrate that the theoretical predication was excellent agreement with the experimental measurement. It suggests that this two-compartment model well describes variation tendency of bilirubin concentration in plasma exchange, and it possesses potential value in clinic application.

Key words: plasma exchange, two-compartment model, bilirubin concentration