Abstract:

The aim was to approach the effect of lipid-lowering treatment on insuli n resistance in patients with type 2 diabetes mellitus. Eighty-four type 2 diab etic patients associated with dyslipidemia were treated by antihyperlipoidemics. 49 patients were treated with 20 mg simvastatin and 35 patients were treated wit h 0.2 g fenofibrate per day. The antihyperglycemic and antihypertensive ther apies were maintained. Before and after the treatment, all of patients w ere examined body mass index(BMI), waist-line/hip-line rate(WHR), blood pressu re, glycosylated hemoglobic (HbA1c), plasma fasting insulin (FINS), total choles terol(TC), total triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol(LDL-C). After 12 weeks of follow up,the TC, TG, and LDL-C levels decreased obviously(P<0.01). HDL-C level in creased obviously in the lipanthyl group (P=0.037). The plasma fasting insul in level decreased from (10.93±5.03) to (9.28±4.26) IU·L^-1 (P<0.01). There were no difference in the fasting plasma insulin level when the simvast atin treated group were compared with the fenofibrate treated group. It suggests that the resistance of insulin improves lipid-lowering treatment in type 2 dia betic patients.

Key words: lipid-lowering treatment, insulin re sistance, dyslipidemia, type 2 diabetes mellitus