Journal of Capital Medical University ›› 2005, Vol. 26 ›› Issue (2): 167-170.

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Effect of Chinese Herb-catechu Extract on Influenza A Virus

Zhao Wenming1, Zheng Qun1, Liu Zhenlong1, Ping Guoling1, Ding Lixin2, Shi Weixian2, Liu Hailin2   

  1. 1. Department of Microbiology, Capital University of Medical Sciences;2. Ding Lixin, Shi Weixian, Liu Hailin Beijing Centers for Disease Control and Prevention
  • Received:2004-03-22 Revised:1900-01-01 Online:2005-04-24 Published:2005-04-24

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Abstract:

Objective To investigate the inhibitory effect of catechu extract to influenza Avirus. Methods The inhibitory cytopathic effects (CPE) of catechu extract on influenza Avirus were observed by MDCK cell culture techniques. The inhibiting influenza Avirus effect of catechu extract was observed by means of chick-embryo culture, and the inhibitory activity of catechu extract on influenza Avirus in vitro was observed by the hemagglutination inhibition test. Results 1) Cytotoxicity of catechu extract was lower and the catechu extract could inhibit influenza Avirus from infecting MDCK significantly. 2) The catechu extract showed significant inhibition on the influenza Avirus in the groups within the limits of dose on chick-embryo culture and the hemagglutination inhibition titer was over 8 times higher than the control group. 3) The catechu extract had distinctly inhibitory functions on influenza Avirus, and the hemagglutination inhibition titer was over 16 times higher than the control group. Conclusion The chinese herb-catechu extract has strong effect on anti-influenza Avirus.

Key words: catechu extract, influenza A virus, MDCK cell culture techniques, chick-embryo culture, hemagglutination test

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