Abstract:

Objective To study the common changes in pathology of dysfunctional uterine bleeding(DUB) caused by endocrine disturbance and birth control medicine (Norplant). Methods Histology and immunohistochemistry were used to demonstrate the expression of CD34 in endothelial cell, laminin in basement membrane in endometrial vessels as well as morphometric analysis of the endometrium of DUB (contraceptive and endocrine disturbance). Results The bleeding caused by birth control medicine(Norplant)was diffuse and the growth of these endometrium was inhibited, while the bleeding caused by endocrine disturbance was localized and the growth of those endometrium appeared different state. The common ground of the two groups was that the blood vessels in bleeding position were not integrative and the expression of CD34 in endothelial cell and LNin basement membrane in blood vessel were distinctly weakened. Conclusion Whatever the inducement of DUBis, the direct changes of DUB is the decreasing of CD34 in endothelial cell and LNin basement membrane of capillary vessel.

Key words: dysfunctional uterine bleeding, CD34, laminin