Abstract:

Objective To evaluate the efficacy and safety of domestic-manufacture gatifloxacin tablet in the treatment of acute bacterial respiratory and urinary tract infections. Methods A randomized and controlled clinical trial was conducted to compare the gatifloxacin and levofloxacin for the treatment of patients with acute bacterial respiratory and urinary tract infections. The dose of both agents was 200 mg twice daily per os. The duration of the therapy was 5 to 14 d in both groups. Results Forty-three patients were enrolled in this study after excluding 1 case of negative bacterial culture, 1 case with incomplete CRF. The patients were divided into gatifloxacin group(n=25) or levofloxacin group (n=26). The overall effective rates and bacterial clearance rates were 100% and 94.4% in gatifloxacin group, 96.2% and 89.5% in levofloxacin group, respectively whereas the adverse drug reaction rates were 0 and 3.8%, respectively. No statistical significances were found in above data. Conclusion Gatifloxacin and levofloxacin were effective and safe for the treatment of acute bacterial respiratory and urinary tract infections.

Key words: gatifloxacin, levofloxacin, randomized controlled trial