Abstract: Objective To compare the alterations of coagulation function and electrolytes during hypervolemic hemodilution induced by polyglucose and sodium chloride infusion(groupⅠ) and 6% hydroxyethyl starch(groupⅡ).Methods 24 neurosurgical patients were randomly allocated into two groups.Hypervolemic hemodilution was induced by rapid infusion(25 mL/min) with PG(groupⅠ, n=12), 6% HES(group Ⅱ, n=12) after general anesthesia.Hematocrit(HCT), activate partial thromboplastin time(APTT), prothrombin time(PT) and serum electrolytecalcium concentrations were determined in whole procedure.Results After(1500) mL PGwas injected, HCTdecreased by 21.5%, Ca²⁺ decreased by 16.7% while APTT, PTincreased by 12.1% and(15.5)% respectively.After 1500 mL HESwas injected HCTdecreased by 27.3%, Ca²⁺ decreased by 12.5% but APTT, PTincreased by 21.4% and 16.3% respectively.Conclusion The hemodilution effects of polyglucose and sodium chloride infusion on coagulation and electrolytes are weaker than the effects of 6% hydroxyethyl starch.However, the coagulation function of 6% HESis stronger than that of PG.

Key words: hypervolemic hemodilution, coagulation, electrolyte, hydroxyethyl starch