Abstract: Objective To observe the effect of blood pressure reduction induced with high epidural anesthesia and general anesthesia in patent ductus arteriosus(PDA) ligation operation.Method 40 infants were randomly assigned to two groups(group Ⅰ with high epidural anesthesia and group Ⅱ with general anesthesia).Results There were no significant difference between two groups on controlled reduction of blood pressure.In group Ⅰ, blood pressure increased steadily compared with group Ⅱ.And recovery time were much shorter.Conclusion High epidural anesthesia for PDA ligation can hardly affect cardiovascular status and blunt the stress response.

Key words: reduction of blood pressure, controlled, epidural anesthesia, patent ductus arteriosus, infants