Abstract: Objective To investigate alterations the changes of cerebral blood flow and vasoactive neuropeptides during retroperitoneal CO₂ insufflation.Methods 19 patients undergoing retroperitoneal laparoscopy were selected.Vmean、Delt and PI were measured with TCD,and endothelin(ET),neuropeptide Y(NPY),calcitonin gene-related peptide(CGRP),neurotensin(NT) in plasma measured before CO₂ insufflation,after CO₂ insufflation,and after CO₂ deflation.Results Vmean and Delt increased significantly after CO₂ insufflation and PI decreased significantly.The plasma concentration of ET 、NPY、CGRP and NT increased significantly at different times.Conclusion Cerebral blood flow is increased significantly in patients undergoing retroperitoneal laparoscopy,which is correlated to alterations of PaCO₂、plasma vasoactive neuropeptides.

Key words: CO₂ insufflation, cerebral blood flow, endothelin, calcitonin gene-related peptide, neuropeptide Y, neurotensin