Abstract: Objective To study the therapeutic effects of progesterone on menstrual cycle disorder and perimenopuasal syndrome in perimenopausal women.Methods 122 subjects with menstrual cycle disorder and perimenopuasal syndrome were divided into two groups: Group A(54 cases) with menorrhagia and endometrial proliferation,who was diagnosised with D & C.They took norethisterone 6～8 mg/d for 22 d per month for 2 cycles,and then changed into medroxyprogestone 6～8 mg for 10 d for 1 cycles during day of cycle 16 d.Group B(68 cases)with irregular cycle or oligomenorrhea,menstrual flow was normal or slight increased or decreased.They received medroxyprogestone 6⁸ mg for 10 d for 3 cycles during day of cycle 16 d.The serum concentration of FSH,LH,E₂ were compared before and after treatment(85 cases).The greene score were performed in two groups(94 cases) who had primenopuasal syndrome before and after treatment. Results FSH was significantly lower(P<0.01),and E₂ was significant higher(P<0.05),LH was decreased,but no significant defference(P>0.05) before and after treatment.In both groups,the symptoms of 94 subjects with perimenopuasal syndrome(77%)were alleviated after treatment,the Greene score were significantly decreased(P<0.01),no significant difference was observed between two groups.Extended menstrual flow was decreased,and disorder of menstrual cycles kept regular for several months after taking progesterone.Conclusion Taking progesterone can alleviate symptoms of perimenopuasal syndrome,regulate menstrual cycles,and protect uterine endomitrium in perimenopausal women.

Key words: progesterone, perimenopausal syndrome, disfunctional uterine bleeding