Abstract:

Objective To study the effects of different xiaoshi Fanshi Powders which consist of different components on hepatic pathological damage caused immune hepatic injury in mice. Methods Firstly, ICL mice were selected and randomized into seven groups: normal control group,model group, Huoxiao Baifan group, Huoxiao Lufan group, Mangxiao Baifan group, MangxiaoLufan group, and bifenbate group. Secondly, one day after intravenous injection of BCG, the equal amount of saline was given for gastric perfusion to the normal control group and model group. The corresponding medicines were given for gastric perfusion to the other groups. At last, The liver was reserved for routine light microscopy so as to determine the pathological damage degree of liver tissue. Results Huoxiao Baifan group could alleviate pathological damage of liver tissue in mice. Conclusion These results suggest that Huoxiao Baifan powder has a markedly protective effect on immune hepatic injury in mice.

Key words: immune hepatic injury, bacille calette-guerin, lipopolysaccharide