Magnetic Resonance Imaging of Atherosclerotic Plaques with Superparamagnetic Iron Oxide Particles in Rabbit Model

Abstract

Abstract:

Objective To investigate the possibility of superparamagnetic iron-oxide(SPIO) particles as a marker of atherosclerotic plaques detected with 1.5T magnetic resonance imaging system in New Zealand white rabbit model.Methods Model of atherosclerosis were established by injuring the right carotid artery endothelium with balloon and feeding with high lipid diet.Five rabbits(group A) were intravenously injected SPIO;and the other five rabbits(group B) received the same volume of saline injection.The MR imaging was performed at 24,48 and 72 hours after injection,and then,histological study was done.Results Twenty-four hours after the intravenous injection of SPIO,3 rabbits in group A showed signal intensity loss in the right carotid artery wall on T₂^*WI,corresponding to Perl's Prussian blue staining-positive particles in the plaques revealed by histopathological study.T₂^*WI change and Perl's Prussian blue staining-positive particles in the plaques were not observed in any one model in group B.Conclusion It is possible to use superparamagnetic iron-oxide (SPIO) particles as a marker of atherosclerotic plaques detected with 1.5T magnetic resonance imaging system in New Zealand white rabbit model.

Key words: atherosclerosis, magnetic resonance imaging, superparamagnetic iron-oxide(SPIO), animal experiment

CLC Number:

R445.4

Ma Zhanlong;Teng Gaojun;Mai Xiaoli;Sun Junhui;Zhang Hongying;Yu Hui;Li Guozhao. Magnetic Resonance Imaging of Atherosclerotic Plaques with Superparamagnetic Iron Oxide Particles in Rabbit Model[J]. Journal of Capital Medical University, 2007, 28(6): 727-731.

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Magnetic Resonance Imaging of Atherosclerotic Plaques with Superparamagnetic Iron Oxide Particles in Rabbit Model

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