Abstract: Objective To investigate the value of ¹⁸F-FDG and 4'-schiff-O[¹¹CH₃]PET imaging in the evaluation of Alzheimer's disease rat model.Methods Ten AD rat models and 10 control rats had undergone the ¹⁸F-FDG and 4'-schiff-O[¹¹CH₃]PET studies.The sections of the brain tissues of both control and AD model rats were stained with HE and Congo red.Results PET imaging of AD rats showed reduced glucose metabolism and high uptake of 4'-schiff-O[¹¹CH₃] in the injected side.Diffuse neuronal loss and Aβdeposition were detected in the hippocampi and cortices in the AD rats;in contrast,such changes were almost not seen in control rats.Conclusion ¹⁸F-FDG and 4'-schiff-O[¹¹CH₃] PET imaging,combining with the behavioral and pathological observations can set up standards of verifying the AD rat model,and it provides a molecular imaging tool for the basic research and clinic diagnosis of AD.

Key words: Alzheimer's disease, AD rat models, Aβ_1～40, 4'-schiff-O[¹¹CH₃], ¹⁸F-FDG, PET